Senior Scientist - Translational Oncology - Precision Medicine

Job Description

Company DescriptionAbbVies mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on peoples lives across several key therapeutic areas ? immunology, oncology, neuroscience, and eye care ? and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and . The Precision Medicine organization within AbbVie is committed to driving translational research and clinical biomarker strategy for our pre-clinical and clinical stage programs. The Translational Research group within Precision Medicine Oncology department uses advanced technologies to study cancer biology, discover biomarkers and validate mechanisms of action of AbbVie?s innovative oncology pipelines to inform clinical decisions, including biomarkers, indication/patient selection, and combinations. The Waltham, MA site is dedicated to Translational Science and Precision Medicine for antibody drug conjugates (ADC) and related anti-tumor agents in solid tumor indications.We are seeking a highly motivated and experienced Senior Scientist with a strong scientific background in cancer biology, a passion for translational research, and a proven track record of research accomplishments to join our dynamic team in Waltham, Massachusetts. The successful candidate will work both within the Translational Oncology group and as a member of cross-functional interdisciplinary teams.RESPONSIBILITIES INCLUDE:

• Independently devise, execute, and analyze hypothesis-driven translational research experiments to identify pharmacodynamic (PD) biomarkers, mechanisms of sensitivity and resistance and test novel drug-combinations to advance the Abbvie oncology pipeline.
• Design and execute in vitro and ex vivo experiments to determine effect of drugs using relevant cell biology techniques. Lead the development, optimization, and validation of new assays.
• Apply cell and molecular biology techniques to identify and evaluate biomarkers.
• Be versed in the current state of the science of functional genomics and omic analysis.
• Routinely utilize broad technical expertise in tumor cell/immune cell biology to advance translational research for both pre-clinical and clinical stage oncology projects.
• Initiate and maintain collaborations with cross-functional teams such as clinical biomarkers, in-vivo pharmacology, bioinformatics and DMPK to ensure alignment on scientific rationale and data generation workflows.
• Effectively communicate hypotheses, work plans and data generated to diverse audiences in both oral and written communications.
• Train and guide colleagues on established methodologies, troubleshoot assays and establish novel techniques within Abbvie or at CROs.
• May mentor/supervise one or more scientist.

QualificationsBasic Qualifications:

• Bachelor?s Degree or equivalent education and typically 10-12+ years of experience, Master?s Degree or equivalent education and typically 8-10+ years of experience, PhD and typically 0-4+ years of experience.
• Exceptional technical precision using standard techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, etc.) primary cell culture, tissue processing, as well as standard molecular biology and biochemical techniques.
• Ability to:
  • Demonstrate and implement critical thinking skills.
  • Learn, understand, and master new areas of biology and experimental techniques.
  • Articulate scientific rationale with clarity.
  • Work independently and proactively on multiple projects in a fast-paced environment.
  • Ability to thrive in a multi-disciplinary, matrixed environment.
• Expertise in oncology and cancer signaling pathways or prior exposure to translational research/biomarker discovery.
• Knowledge of analytical software for routine data analysis is desirable.
• Demonstrated scientific writing skills and strong verbal communication skills.

Preferred Qualifications:

• PhD with 4+ years of postdoctoral research experience in oncology or related field in academia or pharma industry.
• Demonstrated excellence and productivity in independent research.
• Broadly trained in cell biology and translational oncology, as indicated by peer reviewed publications in recognized journals and presentations at national and international conferences.
• Hands-on experience in generating and analyzing multi-parameter gene and protein datasets is highly desirable (RNASeq, Nanostring, FACS, etc.)

Position will be hired based on level of experience. Sr Scientist I or Sr. Scientist IIAdditional InformationApplicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ??

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.?
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.?
• This job is eligible to participate in our short-term incentive programs. ?
• This job is eligible to participate in our long-term incentive programs?

?Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Company?s sole and absolute discretion, consistent with applicable law. ?AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie?s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:https://www.abbvie.com/join-us/reasonable-accommodations.html

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