Scientist II - Biologics LCMS Bioanalysis and Characterization

Job Description

Company DescriptionAbbVies mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on peoples lives across several key therapeutic areas ? immunology, oncology, neuroscience, and eye care ? and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and . AbbVie Inc is embracing new paradigms and technologies to develop novel and life-changing therapies across a diverse range of therapeutic areas. The Quantitative, Translational ADME Sciences (QTAS) department at AbbVie is seeking a highly motivated and energetic bioanalytical scientist to join the biologics characterization and bioanalysis group. The main function of this position will be to develop and implement LC-MS (liquid chromatography-mass spectrometry)-based bioanalysis and in vitro characterization assays of biologics entities, including monoclonal antibody, multi-specific antibody, antibody drug conjugate (ADC), lipid nanoparticles (LNP), Adeno-Associated Virus (AAV) etc. The ideal candidate will be experienced in the optimization and implementation of novel and routine LC-MS-based bioanalytical methods to support in-vivo PK and TK studies as well as in-vitro stability characterization of biologics and genetic medicines. The candidate will be responsible for routine sample preparation, method development, instrument maintenance, data analysis, writing reports, and presenting data at internal and external meetings.Key tasks and responsibilities:

• Optimize and implement bioanalytical methods for quantifying therapeutic drugs (including but not limited to antibodies, ADCs, fusion proteins, LNPs, and small molecules) in biological matrices using LC-MS MRM assay.
• Perform high-throughput sample preparation in both biofluids and tissues to support both PK/PD and proteomics studies.
• Support biologics and genetic medicine drug development by developing in vitro characterization assays using high resolution MS systems.
• Routinely operate LC-MS and automation instruments, including maintenance and troubleshooting.
• Write and maintain protocols and facilitate assay optimization and implementation to ensure data quality.
• Utilize and maintain electronic laboratory notebooks and LIMS systems for study documentation.
• Communicate data interpretation internally and externally.

Qualifications

• Degree in chemistry, pharmacology or other related fields. BS with 8+ years in a pharmaceutical industry setting with a focus on mass spectrometry.
• Highly motivated individual with a strong intellectual and technical background in bioanalytical and characterization methods development, specifically for antibodies, LNP, AAV and oligonucleotide using LC-MS/MS. Must have direct experience in both small and large molecule quantitation (in biological matrices), peptide mapping, PTM analysis, intact/reduced protein analysis (in biological matrices) and lipid profiling in LNPs.
• Deep and broad knowledge in separation science and mass spectrometry. Extensive hands-on experience in maintaining and troubleshooting SCIEX Triple Quad b5500/6500/6500+, Agilent QTOF 6545/6550 and Thermo Orbitrap mass spectrometers is required.
• Experience in performing immunoaffinity purification and sample preparation using automation systems (including but not limited to AssayMap Bravo and TECAN) is a must.
• Experience in using LIMS system for sample and data management is a must.
• Strong data analytical skills are required. Experience with Skyline, Protein Metrics, Analyst, Xcalibur and MassHunter is preferred.
• Knowledge in drug discovery and related disciplines. In-depth understanding in vivo PK, TK studies and corresponding bioanalytical assays is preferred.
• Excellent verbal and written communication skills, strong analytical and organizational abilities, and the ability to work independently and thrive in a team environment.
• Desire to excel in a fast-paced environment, with strong problem-solving skills, and the ability to prioritize tasks and meet deadlines effectively.

Additional InformationApplicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ??

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.?
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.?
• This job is eligible to participate in our short-term incentive programs. ?

?Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Company?s sole and absolute discretion, consistent with applicable law. ???AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie?s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:https://www.abbvie.com/join-us/reasonable-accommodations.html

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